Book Description

From the Reviews of Previous Volumes
"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."
-JOURNAL OF MEDICAL MICROBIOLOGY
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."
-SCIENCE
"A provocative and scholarly review of research."
-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching."
-JOURNAL OF IMMUNOLOGIC METHODS ... Read more

Book Description

Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field. ... Read more

Book Description

During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer?s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters. ... Read more

Book Description

Here is the most complete reference devoted specifically toviral pathogenesis, describing both the development of viral diseaseand the host/virus interaction. Presenting contributions from leadingauthorities in this particularly topical field, this comprehensive textexposits the current knowledge on the pathogenesis of viruses, anunderstanding of which is critical to treatment and prevention of viraldiseases.The book opens with a thorough review of principles, coveringin detail the life cycle of viruses, including entry, dissemination,shedding and transmission, and replication; the pathology of viraldisease, including disease mechanisms, virus virulence, and viraloncogenesis; immune responses, including immune suppression; andtherapeutic applications. The second section focuses on experimentalpathogenesis, covering detection and quantification of viral genomes,messages, and proteins in tissues and organs; and examining classicaland new methods for animal studies. Chapters in the next section,devoted to classical models of viral pathogenesis, cover ectromelia,poliomyelitis, rabies, lymphocytic choriomeningitis virus, avian andmurine retroviruses, lentiviruses, and reoviruses. The final sectioncovers systems pathogenesis, emphasizing viral diseases of humans butalso drawing on animal studies that elucidate the pathogenesis of humaninfections. ... Read more

Book Description

Praise for the Series:
"This serial... is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology... Timely, informative, and useful to student, teacher, and research scientist."
--American Scientist
"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology."
--Military Medicine

Key Features
* Among the topics covered are:
* Virus-induced immunopathology
* Filoviruses
* Molecular characterization of pestiviruses
* Transactivation of cellular genes by hepatitus B virus proteins
* Principles of molecular organization, expression, and evolution of closteroviruses
* Primate T lymphotropic oncoretroviruses
* Replication of positive-stranded RNA viruses of plants and animals ... Read more

Reviews (2)

Puzzled
I am puzzled as to why another reader of this book rated it so badly. I find the text a little heavy to grasp at first but this book belongs to a series of up to date texts bringing to the attention of the reader important discoveries and concepts in this field. I think to rate the book you must consider the fact that it is one collection in a series of collections of papers on virology that are detailed and for a scientific audience. Personally, I found the books an excellent reference.

virus
introdution in virus lis ... Read more

Book Description

Resulting from a Royal Society discussion meeting, this volume presents a short review of the topic of parasite-host co-evolution. Current thinking on evolution in parasites, viruses and other pathogens is discussed. ... Read more

Book Description

Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field.The editors are recognized experts and the format is comprehensive and instructive. ... Read more

Book Description

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.

Key Features
* Expression, purification, and characterization
* Activity assays
* Kinetic and screening
* Design and analysis of substrates and inhibitors
* Molecular and structural characterizations ... Read more

Book Description

The updated and substantially expanded Second Edition features22 all-new chapters on state-of-the-art immunopathologic testingtechniques and the use of these techniques in diagnosis ofimmunopathologic diseases, immunodeficiencies, organ transplantrejection, and neoplasia. The expanded section on immunopathologicdiseases includes new chapters on vasculitis, dysproteinemias, anddiseases of the liver, lung, and nervous system. A new section onimmunodeficiencies includes a classification system, an updated chapteron inherited immunodeficiencies, a discussion of the immunologicconsequences and immunopathogenesis of AIDS, a description of the keydiagnostic tests for HIV-induced diseases, and new chapters onopportunistic infections and immunodeficiency-related neoplasia.Coverage of organ transplantation, which was limited to the kidney inthe First Edition, now encompasses all organs: the kidney, heart,liver, lung, pancreas, and bone marrow. The section on neoplasiaincludes new chapters on oncogenes, bone and skin tumors, and themolecular biology of leukemias and lymphomas. Other new chapters in theSecond Edition cover adhesion molecules, the complement system,lymphocyte functional assays, and in situ hybridization. Nearly 500illustrations, including over 200 in full color, complement the text. ... Read more

Book Description

This book and its companion, Volume II, concentrate on new procedures--especially those based on the new molecular methodology--developed within the past decade. This volume outlines the approaches, techniques, and procedures applied to cell and molecular biology studies of mycoplasmas. Volume II deals with the new genetic and immunological tools applied to the diagnosis of mycoplasma infections of humans, animals, plants, insects, and all cultures, with particular emphasis on the association of mycoplasmas with the activation of AIDS.

Key Features
* Cultivation and morphology
* Genome characterization and genetics
* Membrane characterization
* Cell metabolism
* Taxonomy and phylogeny
* Pathogenicity ... Read more