Book Description

This excellent reference covers state-of-the-art methodologies for plant and animal glycoconjugate analysis;detailing mass spectrometry, nuclear magnetic resonance spectroscopy, glycolipids and new physical methods, O-glycosylation characterization, chromophore and fluorophore labeling of oligosaccharides, separations, exoglycosidases and mapping, and plant glycobiology. ... Read more

Book Description

This new biochemistry text features a modern, chemical approach, always explaining the underlying chemistry of key biochemical molecules and reactions while taking advantage of recent developments. Features a true thematic and modern approach with a strong emphasis on research.
* Retains core topics of biochemistry, using real examples of chemical reactions and molecular structures.
* Emphasis on depth of coverage, rather than breadth.
* Integrated media provides review of difficult concepts, molecular structure tutorials, and interactive animations. ... Read more

Book Description

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations.This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist. ... Read more

Book Description

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Illustrates the organic mechanism associated with each enzyme-catalyzedreaction
Makes the connection between organic reaction mechanisms and enzyme mechanisms
Compiles the latest information about molecular mechanisms of enzyme reactions
Accompanied by clearly drawn structures, schemes, and figures
Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
Explains how enzymes can accelerate the rates of chemical reactions with high specificity
Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
Shows how chemical enzyme models are used for mechanistic studies
Describes catalytic antibody design and mechanism
Includes problem sets and solutions for each chapter
Written in an informal and didactic style ... Read more

Reviews (2)

A lot of problems will be solved in later revisions
The index for this book .... For example, there are a fair number of examples of the epoxidation reaction, but not a single pointer toward that in the index of the book. And much the same thing for other types of reactions.

It would also be nice if there was a more clear transfer between basic organic principles and then biological applications.

He does do a good job showing this is some cases (i.e., the benzoin condensation), but a few more parallel examples would have been very useful.

Professor Silverman does it again!
This book is an excellent resource for undergraduate and graduate students studying enzyme chemistry and organic mechanisms. Prof. Silverman does a fine job of giving many different examples of enzyme mechanisms. By not focusing totally on one kind of enzyme or catalysis, he succeeds in painting a broad picture for the reader, while not sacrificing content. The only drawback to this edition is the large amount of typographical errors that appear throughout. Perhaps better editing is in order for future editions. ... Read more

Book Description

In one of the first major texts in the emerging field of computational molecular biology, Pavel Pevzner covers a broad range of algorithmic and combinatorial topics and shows how they are connected to molecular biology and to biotechnology. The book has a substantial "computational biology without formulas" component that presents the biological and computational ideas in a relatively simple manner. This makes the material accessible to computer scientists without biological training, as well as to biologists with limited background in computer science.

Computational Molecular Biology series Computer science and mathematics are transforming molecular biology from an informational to a computational science. Drawing on computational, statistical, experimental, and technological methods, the new discipline of computational molecular biology is dramatically increasing the discovery of new technologies and tools for molecular biology. The new MIT Press Computational Molecular Biology series provides a unique venue for the rapid publication of monographs, textbooks, edited collections, reference works, and lecture notes of the highest quality. ... Read more

Reviews (5)

The title says it...
An excellent book for studying computational molecular biology from an algorithmic perspective. (But if you never took mathematics seriously, you are forewarned.)

Good book, but the back cover lies....
As others have noted, the premise that this book is for beginners from either the computational or the biological field is flawed...unless one's definition of beginner is a lot more advanced than mine.

For example even chapter one throws out terms like "recombination" and electrophoresis. without enough explanation for the biology newbie, IMO. Heck, for someone truly new to biology, a bit of time explaining what a chromosome is is probably time well spent.

And for the person coming from a pure biology background, some of the mathematics will definitely be a problem unless they have a decent understanding of combinatorics and discrete mathematics. And that "computational biology without formulas" blurb on the back cover should be read as "not as many formulas as I could have included if I really wanted", rather than "no formulas at all". There are equations galore in this book, rest assured of that.

That said, if a person *does* have the necessary background to make the material accessbile, then the book is definitely worth the purchase. The book's failure is in defining its target audience, not in the material presented.

computational
While this is certainly the do-loop of computational biology the reader would question the assertion that this book provides a common link (no pun) between the biologists need for computational expertise and the programmer's need for biological insight. In either case a solid basis in Discrete Mathematics goes along way here (usually a required course for computer science majors). This reader thinks a similar required course in genetics should be made for engineers to reduce their reductionistic tendencies. However the distinction between these lines grows narrower with each new computer chip. None the less the book is well written, and easy to read (as Discrete Math stuff goes). This book is not for beginners in either Combinatorics or genetics and the last part of the book poses many current questions that as the author says, "are just currently being answered". This book already assumes you know about such things as NIH, PDB, Chime, Isis, NCIB, docking, etc. For those less adapt at programming (myself) the following alternatives are fun, useful and to the point. Both trees and networks can be easily set up in MathCad using their built in resource center add-ins for Combinatorics and Set Theory. They also provide a Traveling Salesman routine in Numerical Recipes that can be applied directly to the problems in Pevzner's book. (Although remembering that most optimization algorithms provide only the most probable 100 out of 2 million it is still fun!). Most of the mappings and node process familiar to Discrete Math can be solved using Mathcad and some sort of adjacency matrix combination. (Including the four-color mapping problem). This provides the basis for most nodal mappings. For the more daring the adjacency matrices can be run through Matlab's GUI's decompositions and analyzed using their optimization toolbox. Currently I'm investigating the Hidden Markovian chains using the Frame advance feature of Mathcad applied to 2D cspline- intercept graphing and updating by frame iteration. This book is for the serious student or solid course material in a related field, and while probably not rated in top ten novels of 2000 certainly rates five mouse clicks from this reader.

Nice book for experts
The title is somewhat misleading because the book is primarily devoted to combinatorial methods that could be used in genome sequencing and genomics. The selection of methods is arbitrary and does not seem to be dictated by either pedagogical or scientific vision. It mainly reflects the author's own work and interests. Contrary to what the editorial review states I find this text quite abstract and formal. I like the book very much but I don't think it should be recommended to the beginners in computational biology. Readers who have a taste for mathematics and a strong background in combinatorics could benefit the most from reading this book. Anybody who looks for a textbook-level guidance in computational biology should probably rely on better designed texts such as Don Gusfield's "Algorithms on strings trees and sequences" or "Biological sequence analysis" by Durbin and co-authors. However, the readers who are interested in mathematics behind designs of DNA arrays (chapter 5) or in mathematical treatment of genome rearrangements (chapter 10) should certainly read this book in detail.

A must have for computational biologists
If you want to understand what is INSIDE those nice software tools available to molecular biologists and now on the web you have to study this book. It's a little more advanced than Gusfield's in some aspects, and more research oriented. Of course it does not cover uniformly all areas of computational biology: if you know Pavel's work, it would be very easy to predict the content of the chapters. For example, more than 50 pages are dedicated to genome rearrangement, but only 10 on multiple sequence alignment. Anyway, this is good, because we can learn about alignment from many other books, in particular the one by Gusfield. I strongly recommend this book to anyone interested in this fascinating field of Science. ... Read more

Reviews (1)

Very High Yield!
High yield cell and molecular biology is exactly what it says, and from the outset doesn't pretend to be anything else. "Lean efficient text" says the blurb, "Study guides with the barest essentials". These words certainly comforted me after reading the somewhat ominous title! The text is compact, with clear and helpful diagrams illustrating and clarifying the most difficult concepts in the book. The style is in fact very much the same as I might choose to write own revision notes, with chapters divided into sub-titles, and those into bullet points. Key words are emboldened, so it is possible to absorb a page by only scanning the bold type; useful if you are caught short when preparing for an exam and need the facts quickly! There is a smattering of clinical examples throughout, and descriptions of procedures such as PCR, which both help anchor your thoughts of the sometimes abstract nature of the subject. Being a molecular biology book it is biased toward genetics, and as this is a confusing area for many students (including me), this will help if your genetics lectures tend to sail several meters over your head. On the downside, the economic nature of the text and the no-frills nature of the diagrams mean that it is not a particularly colourful or engaging read in it's own right. This is also positive, meaning that it is easier to extract information quickly than would be possible from a more bulky text. It is clearly meant to be dipped into, rather than read cover-to-cover. Realistically though, who would read a textbook cover-to-cover? People who will benefit from this book will be pre-clinical medical students, those intercalating a BSc in clinical science or genetics, doctors requiring an up-to-date review, or other students of biomedical science. This should not be your only textbook on cellular biology and genetics, but will serve as the perfect revision tool when exams sidle up too close for comfort. ... Read more

Book Description

This useful reference offers in-depth coverage of the fundamental principles of solute partitioning in aqueous two-phase systems, explains their important practical features, and furnishes methods of characterization. ... Read more

Book Description

This is a book for everyone interested in photosynthesis. The algae are a fascinating group of photosynthetic organisms ranging from some of the largest organisms on our planet down to the microscopic. Much of their diversity rests on their wide-ranging photosynthetic systems. Yet despite an explosion in our knowledge over the last decade, there has been no single book devoted to detailed aspects of algal photosynthesis for over twenty-five years. This book introduces the reader to algal diversity as currently understood and then traces the photosynthetic structures and mechanisms that contribute so much to making the algae unique. Indeed the field is now so large that no one expert can hope to cover it all. The 19 articles are each written by experts in their area; ranging over all the essential aspects and making for a comprehensive coverage of the whole field. Important developments in molecular biology, especially transformation mutants in Chlamydomonas, are dealt with, as well as areas important to global climate change, carbon dioxide exchange, light harvesting, energy transduction, biotechnology and many others. The book is intended for use by graduate students and beginning researchers in the areas of molecular and cell biology, integrative biology, plant biology, biochemistry and biophysics, biotechnology, global ecology, and phycology. ... Read more

Book Description

This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easy–to–use thoroughly reliable laboratory protocols. It contains a fully up–to–date collection of 12 rigorously tested and reliable lab experiments in molecular biology, developed at the internationally renowned Dolan DNA Learning Center of Cold Spring Harbor Laboratory, which culminate in the construction and cloning of a recombinant DNA molecule.

Proven through more than 10 years’ of teaching at research and nonresearch colleges and universities, junior colleges, community colleges, and advanced biology programs in high school, this book has been successfully integrated into introductory biology, general biology, genetics, microbiology, cell biology, molecular genetics, and molecular biology courses.

The first eight chapters have been completely revised, extensively rewritten, and updated. The new coverage extends to the completion of the draft sequence of the human genome and the enormous impact these and other sequence data are having on medicine, research, and our view of human evolution. All sections on the concepts and techniques of molecular biology have been updated to reflect the current state of laboratory research.

The laboratory experiments cover basic techniques of gene isolation and analysis, honed by over 10 years of classroom use to be thoroughly reliable, even in the hands of teachers and students with no prior experience. Extensive prelab notes at the beginning of each experiment explain how to schedule and prepare, while flow charts and icons make the protocols easy to follow.

As in the first edition of this book, the laboratory course is completely supported by quality–assured products from the Carolina Biological Supply Company, from bulk reagents, to useable reagent systems, to single–use kits, thus satisfying a broad range of teaching applications. ... Read more

Reviews (1)

spotless
This book is the best book on the subject on the market. The subject matter is juxtaposed by easy yet informative experiments that can be carried out in a normal scholastic setting. I hear the writers are all hotties. ... Read more

Book Description

Protein NMR Spectroscopy: Principles and Practice combines a comprehensive theoretical treatment of high resolution NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules. Beginning with simple theoretical models and experimental techniques, Protein NMR Spectroscopy: Principles and Practice develops the complete repertoire of theoretical principals and experimental practices necessary for understanding and implementing the most sophisticated NMR experiments. Protein NMR Spectroscopy: Principles and Practice is written as a graduate-level textbook and will be of particular interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy as a research tool or who wish to remain abreast of the latest developments in this increasingly important area.

* Special Features:
* First book to combine detailed NMR theory discussions with experimental applications to biomolecules.
* All the theory required to understand these experiments and others.
* Easy to follow progression from a fundamental level to an advanced level.
* Theory of NMR and practical applications for biomolecular investigations presented.
* Theory applied to very practical situations.
* Comprehensive treatment of different "levels" of theory from simple ideas to density matrix analysis and operator practices.
* Comprehensive description of multi dimensional NMR experiments as applied to unlabeled, 15N-labeled and doubly (13C/15N) labeled proteins. ... Read more

Reviews (1)

Useful Handbook for Protein NMR study
The book is very complete, covers most of the field in protein NMR studies. The book is well organised, with plenty of figures to facilitate easy understanding of the subject. Overall, I find it is very helpful for anyone who will be interested in protein NMR research. I have actually seen quite a number of copies in a few NMR laboratories and I would recommand this book to all those who are looking for an complete introductory book in NMR and protein study. ... Read more

Book Description

Gives medical students 500 questions, answers, and explanations to prepare for the biochemistry and genetics sections of the USMLE Step 1. The new edition includes many new questions in the two-step clinical format to simulate the USMLE Step 1. ... Read more

Reviews (2)

Great question & review book
I found this book very helpful in my step 1 prepertion most of all helped me with Molecular biology questions in my actual test and is also great for genetics, over all the more questions you do from this book the more it boosts your confidence in Biochemistry in the real exam specially if you were like me (an IMG)whose Biochemistry background is weak and feel like practicing more questions, you will definitely make use of this book

helpful and good assistent in your study
it is easy to use and is giving the most popular type of question you need to pass USMLE step I so I recommended it for everybody who wants to pass the step with high score as I am doing . ... Read more

Book Description

Hailed by advance reviewers as "a kinder, gentler P. Chem. text," this book meets the needs of a one-semester course or a full-year course in physical chemistry. It is an ideal choice for classes geared toward pre-medical and life sciences students. Or, as stated in a May 2001 review in Journal of Chemical Education, "this text meets these students where they are and opens the door to physical chemistry from a perspective they can appreciate."Physical Chemistry for the Chemical and Biological Sciences offers a wealth of applications to chemical and biological problems, numerous chapter-ending exercises, and an accompanying solutions manual. Well known for his clear writing and careful pedagogical approach, Raymond Chang has developed yet another masterpiece in chemical education. ... Read more

Book Description

Here are real tools and techniques for counting carbs correctly. New chapters cover how to build a personal carb count database, carb counting for insulin pump users, a whole week of meal plans, and much more.

Reviews (1)

Quick and informative
I bought this book for myself as a gift and my room-mate liked it so much he wants one for himself. It is a nice reference book to quickly look up vitamins and minerals and the effect they have on your body. Not alot of medical jargin to weed through. Alot of information that is useful. Let's you know what to increase/decrease in your diet to combat your symptoms. Great book! Will look at others from this author. ... Read more

Book Description

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.

Book Description

Providing a broad experimental, this book contains a theoretical introduction together with practical protocols, considering all aspects of enzymology. The fundamental experiments in enzymology are presented in very clear and easily realizable protocols, with each experiment accompanied by a section giving the theoretical background.
Essential reading for all scientists and practitioners working with enzymes. ... Read more

Book Description

Plant Biochemistry and Molecular Biology Second Edition Edited by Peter J. Lea Department of Biological Sciences, Lancaster University, UK and Richard C. Leegood Department of Animal and Plant Sciences, University of Sheffield, UK As research in plant metabolism and molecular biology continues to make great progress it has become essential for plant scientists to have an overview of both disciplines, which are becoming increasingly complementary in understanding plant function. Drawing on their own teaching and research experience, the editors and contributors have provided a timely, comprehensive and generously illustrated new edition of this successful introductory textbook. All of the chapters have been updated and revised, and a new chapter on secondary metabolism has been included. Plant Biochemistry and Molecular Biology will be invaluable to undergraduate and postgraduate students in the plant sciences and to all those requiring an introduction to current concepts in molecular plant science. Reviews of the First Edition "The aim of the editors to blend plant biochemistry with molecular biology is successfully reached and provided a new, well written text book which is easy to read." Journal of Plant Physiology "The contributing chapters are well written with clear illustrations and I would expect undergraduates, to whom this book is primarily targeted, to enjoy using it." New Phytologist "The evident teaching experience of the authors make this textbook a useful aid to students and researchers." Photosynthetica What the lecturers said about the First Edition: "A very useful text with a good balance of traditional biochemistry and molecular biology. Its usefulness is enhanced by a very clear and visually pleasing layout and the generally high quality and clarity of the writing." "A surprising amount of information in an easily accessible format." "Good coverage and depth. I'm not aware of any other book that deals with this material so well as this one. It addresses a real need in plant science teaching." ... Read more

Reviews (1)

Plant Molecular Biology
Dear Sir: I am a plant Molecular Biologist and develop transgenic plants. I am looking for a suitable book for my undergraduate, biology majors- on this subject and will be glad to review this book.

Dr. O. Bagasra, MD, PhD ... Read more

Book Description

Actins are highly conserved proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility, from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins. This up-to-date edition gives a comprehensive account of actin sequence, mutation, and structure as well as providing insight into ligand-binding sites and drug and toxin binding. ... Read more

Book Description

The emergence of genomics, the study of genes, is one of the major scientific revolutions of this century. Microarrays, a method used to analyze numerous DNA samples rapidly, enables scientists to make sense of this mountain of data using statistical analysis. They are being used in such areas of biomedical research as studying patterns for gene activity that cause cancers to spread. This book presents a comprehensive methodology for analyzing DNA microarray and protein array data.
The most comprehensive treatment of this important emerging field, Exploration and Analysis of DNA Microarray and Protein Array Data includes:
A review of basic molecular biology and a chapter introducing microarrays and their preparation
Chapters on processing scanned images, preprocessing microarray data, group comparative experiments, and other designs
Discussions of clustering, protein arrays, and applications for diagnostic tools
Ample exercises assist absorbtion ... Read more

Reviews (1)

Excellent!
This book provides an excellent overview of various methods in DNA microarray analysis. ... Read more