Book Description

This book is unique in linking in vivo ¹³C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders.

• Novel and potentially controversial
• Will inspire future research directions

Book Description

DNA microarrays have revolutionized molecular biology and are becoming a standard tool in the field. Dov Stekel's book is a comprehensive guide to the mathematics, statistics and computing required to use microarrays successfully. Unlike traditional molecular biology, the successful use of DNA microarrays requires the application of statistics and computing to design the arrays and experiments, and to analyze and manage the data. This book is written for researchers, clinicians and laboratory managers. ... Read more

Reviews (2)

A Good Book for Microarray Bioinformatics
I rate this book a 5 star because I believe this book is one of best bioinformatics books which make it possible for the biologists to understand the bioinformatic tools inside of microarray technology. For me the most useful chapters include Sequence Databases for Microarrays, Computer Design of Oligonucleotide Probes, Normalisation, Measuring and Quantifying Microarray Variability, Analysis of Differentially Expressed Genes. As a three-years microarray user, I still get a lot information after I read this book. However, no any bioinformatic books are perfect and complete. There are also some limitations in this book. The author sometimes did not provide detailed information on some biostatistic analysis tools and only provided some references for reading. Since a lot of bioinformatic tools are still in the trial stage and need to be improved, we can not blame the author for the incompleteness.
As a 250-pages bioinformatics book, I believe, this book is very informative and useful for microarray users and biologists who are tired of understanding the abstract biostatistic equations.

Microarrays Lite
It just doesn't have the detail I wanted.

There's a lot to like here. Stekel covers everything, starting with selecting the probes and printing the arrays. Next comes raw array analysis - scanning, image processing, and measuring the effects of the array itself on the results. That covers the first six chapters. The next three go over analysis of the result, one more chapter covers experimential design, and the last chapter discusses storing, labelling, and sharing the data. Some of those topics, like experiment design, address issues that most other authors neglect.

Still, I came away feeling that I had read only half of each chapter. Going back, it turned out that I hadn't missed anything that really was there. I missed a lot, though. For example, probe selection includes a discussion of self-hybridization - good stuff. It stopped short of giving me any clear idea how much self-complementarity is too much. It mentioned DNA melting points, but without enough information for me to understand what is really melting, or how or why to choose one melting point over another. Handling of raw array data discussed Loess regression as a way to cancel out process differences across a single array. Again, it's good stuff, but what exactly is a Loess regression? Expression analysis mentions Spearman correlation as an alternative to Pearson correlation - it give Pearson's formulas, but not Spearman's. Later, when the author does give a "formula" for selecting sample sizes, it turns out to be some macro reference for some stat package. Throughout the book, I felt the same lack: I learned the names of many things, but not what they really are.

Maybe this book is OK for a first introduction. If you've had that introduction and want to take the second steps, this book probably won't meet your needs. ... Read more

Reviews (6)

Highly recommend it
Hands down the bible of enzyme kinetics!

Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.

essential
If you are studying protein structure, you probably should read this book for reference.

This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.

Some texts are difficult to understand, or dry, or facile. This is not one of those texts.

Biochemists Can't Miss
The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.

Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.

Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

The Mother of All Enzyme Books
Man, this book rocked! I took one look at the ribbon structure of ATPase on the cover and said to myself, "Whoa dude! This is, like, phat!" Then I turned the pages and BAM! I was knee deep in protein structure! Like, any first-year biochemist knows its all about the acids, as in amino, and Fersht, he knows his peptides! Oh man, I was on cloud nine! And I've been off my meds for two months now! But you wanna know the real dope? You can't say diddly about function unless you know structure, and that Alan, as in Fersht, dude! Like, he starts you off simple, like, you know, with the "building blocks," like we're a bunch of two-year-olds, and you string 'em together and get all that higher-order structure and stuff, and slowly, ever so slowly, like a mental itch that invades your consciousness and becomes screaming voices telling you to AHHHHHHHHH! So many domains! Too many functional units! No, no, nooooooo! Schiff base? Shift Bass! Ah HA HA HA HA! What do all those K's mean!?! Take me home! Please...

A classic - one of the "top ten" books for biochemists !
This book belongs in every protein biochemists collection. It is a clear, up-to-date review of protein structure and function, with a concentration on enzymes. It covers a host of vital topics, including: the theories of chemical catalysis, enzyme kinetics (buy Segal for an in-depth study of this topic), the methods for determining rate constants, the stereochemistry of enzyme reactions, various regulation mechanisms, binding energies and the forces between molecules, and an overview of protein engineering techniques. If all this were not enough, Fersht concludes with a wonderful chapter covering case studies of enzyme structure and mechanism, and another couple on the kinetics and mechanisms of protein folding. Extensive references are given to the current literature for further study.

Putting all these topics into one book is an accomplishment that few authors could pull off - but Fersht does it extremely well!

Oh - the other nine ?

Cornish-Bowden, "Principles of Enzyme Kinetics"; Segal, "Enzyme Kinetics"; Voet & Voet, "Biochemistry"; Branden & Tooze, "Introduction to Protein Science"; Dixon & Web, "Enzymes"; Pauling, "The Nature of the Chemical Bond"; Scopes, "Protein Purification"; Freifelder, "Physical Biochemistry"; Walsh, "Enzymatic Reaction Mechanisms" ... Read more

Book Description

This text provides explanations and examples of the primary chromatographic techniques for biomolecules (reversed-phase, size exclusion, ion-exchange, hydrophobic interaction and affinity).It also offers practical suggestions for their implementation and optimization.An extensive bibliography furnishes a wealth of background information. ... Read more

Reviews (2)

So brilliant that I cried--twice!
This is without a doubt the most brilliant and poignant depiction of HPLC and CE of biomolecules in modern history. My extreme hyperactivity disorder usually means that I'm not able to sit still for such weighty topics--not without large amounts of abused Ritalin; but Cunico's work was so compelling and finely wrought that I found myself spellbound, even when drunk, even when driving in the backseat of a stolen car across the Mexican border at Tecate. I am not going to recommend drinking heavily and stealing cars. But I do recommend BASIC HPLC and CE OF BIOMOLECULES by Robert L. Cunico. By the way, I am extremely drunk right now.

Basic HPLC and CE of Biomolecules
This is a book that should be on the desk of anyone who is involved in analytical development of biomolecules and biopharmaceuticals. The content is well organized and written in a format that is easy to grasp and understand. The content covers almost all the different modalities of HPLC analyses and applications and provides real life examples of the techniques. It includes innumerable suggestions on how best to develop a validatable HPLC method and analyze the data appropriately.

I would highly recommend this book to both new and old members of biotechnology, especially the developmental, analytical, and quality assurance groups where there is frequently a need to implement a solid reliable method for analyzing biomolecules in a more rational fashion. ... Read more

Book Description

This book presents the statistical methods that are useful in the study of molecular evolution and illustrates how to use them in actual data analysis. It is appropriate for graduate students and researchers (assuming a basic knowledge of evolution, moecular biology, and elementary statistics), allowing many investigators to incorporate refined statistical analysis of large-scale data in their own work. ... Read more

Reviews (4)

A valuable addition
I don't look for any one book to answer all my questions. This one carries its weight, though, and maybe a bit more.

The first section gives the clearest and most detailed description of nucleotide sequence comparisons I've seen. I'm no biologist, but it really got me thinking about some new ways to talk about substitution matrices.

The bulk of the book covers what I hoped for originally: phylogenetic trees. The authors choose an unusual approach - it doesn't quite meet the authors' initial promise of math-minimization, but doesn't climb too far up the ivory tower, either. I find it a very practical, usable level of presentation. I'd be nervous about going beyond their formulas, since the math for real understanding isn't all there. Still, the phylogeny discussion covers a lot of material, and covers it well enough for me to write programs about most of it.

The final section addresses population genetics. I have nothing against population genetics, it just never seemed to point where I'm headed. Nei and Kumar corrected my mis-impression. Population gentics is the background model, the null hypothesis, behind the functions that score population differences. It really shows what happens when the tree of life branches out.

The book has some minor weaknesses. It emphasizes nucleotide sequences at the expense of peptides; I can't fault an author for writing what they want as opposed to what I want. On page one, the authors decline an intensely mathematical approach. By page 25, they're up to Poisson and gamma distances. The typography make the section breaks into a "Where's Waldo" experience. Nei's favorite author, based on citations, is Nei. Well, false modesty is no virtue. This book seems authoritative and Nei seems to be an authority, maybe not just in Nei's opinion.

This book really has given me a lot more to work with than most. Education isn't cheap these days, and this book is very educational. I just hope no one asks me to lend it any time soon.

OK, until something better comes along
Nei and Kumar's "Molecular Evolution and Phylogenetics" is basically an updated version of Nei's 1987 "Molecular Evolutionary Genetics" book. Accordingly, attention is shifted to reviewing many recent advances in methods of phylogenetic inference with an obvious bias towards distance methods, particularly those which the senior author devised. In fairness, they give decent coverage to the more popular parsimony and likelihood methods as well. The great strength of the book is the number of real examples used to illustrate properties of the methods, and their focus on statistical methodology without miring the reader in detailed mathematics. The disappointment is that while breadth of coverage is tolerable, depth is lacking. Expanding their views on the shortcomings of likelihood in choosing tree topology and likelihood ratio-tests in choosing models of sequence evolution would have been most enlightening, particularly as these issues have been brushed lightly aside by phylo-likelihoodists. Other methods (Hadamard transformations, Bayesian phylogenetic inference) were absent altogether. Further the chapter on molecular clocks was disappointing--old 1980s controversies were rehashed, while there was nothing on methods that relax the assumption of rate constancy while still allowing divergences to be dated. Admittedly some of this is very new and research is ongoing, but there isn't even a hint of these developments in this chapter. Another plus though is the addition of a chapter on inferring ancestral states of molecular sequences.

Unlike Molecular Evolutionary Genetics, far too little of the book is devoted to methods at the population level, and what is there again smacks of state-of-the-art 15-20 years ago. I was hoping for much more coverage of microsatellite and AFLP data. There was very little for either, while now rarely-used RFLPs were given extensive coverage.

In short, this book was too short, particularly for the price, and I almost gave it 3 stars rather than 4. However, if you are a phylogeneticist, you will probably want to have this book on your shelf. A lighter introduction for the uninitiated would be Rod Page's "Molecular Evolution" or Graur and Li's "Fundamentals of Molecular Evolution". However, my hopes for a good comprehensive text and reference on phylogenetic methods now rest on publication of Joseph Felsenstein's "Inferring Phylogenies".

Top in its Field
This book is an excellent text and reference for both graduate students and faculty. It covers several topics in molecular evolution and phylogenetic analysis, as the title suggests. It stands as a unique contribution because the authors explain the mathematical and conceptual framework of a given topic in molecular evolution or phylogenetic analysis and give subsequent examples to show how various analytical methods can be applied to the study of that topic. In that context, the explanation of concepts was exceptionally clear, which made it easy to understand potentially difficult subject matter. This book is highly recommended to those wishing to study the analysis of genes and proteins in an evolutionary framework.

An advanced textbook for graduate students.
This is an advanced textbook on population genetics and molecular evolution. It is best recommended for graduate students with some background in population genetics and statistics. It gives a broad and thorough view of the field of molecular evolution and phylogenic different models up to date. The authors have included a lot of numerical examples to demonstrate the principles of the various models dealt with (mainly by using the MEGAII software), which helps a lot to relate to. Unlike some other general textbooks of population genetics, this book indeed concentrate mainly on phylogenic analysis and hence it's uniqueness and advantage. ... Read more

Book Description

This is a new and up-to-date edition of the best selling "Instant Notes in Biochemistry," providing a valuable revision and information source for all undergraduates taking biochemistry courses. This best-selling Instant Notes book has now been thoroughly updated and reorganized for improved clarity. Many topics have been completely rewritten and new topics on RNA synthesis and processing, and thermodynamics have been added. Remaining concise yet comprehensive, Instant Notes in Biochemistry 2/e continues to provide easy access to the core information required by all students in the life sciences. The format remains ideal for learning and rapid review. ... Read more

Reviews (5)

Excellent overview
People often make the mistake of hitting the bigger books with the hope that they will gain a more complete understanding of a subject. However the problem with such an approach (particularly when beginning a subject) is that more often than not, one loses sight of the key concepts and broad principles. This where i feel this book is a gem. The strength of this book is that each chapter succinctly provides you with all the main points you need to know about each subtopic. In this way you are given a solid basis and contextual understanding, enabling you to gain a deeper appreciation of biochemistry from larger texts.

At the start of each biochem topic in your course, read the corresponding chapter in this book first, then use your lecture notes or larger texts to fill the gaps/details.

This happens to be one of a very few review books i've kept in my extensive library.

Dr A.M.

Tight, concise, pretty nice, right price.
This book is a super concise quick read on the subject. It covers the main points without boggling you with information overload on deatils. I wish it would show more chemical structure at times to make the logical of transformations more transparent;in the metabolism sections particularly. The graphics are minimalmistic, this mode is not exploited by the authors. It does not make much of an attempt to help you better understand the logic of the subject in the metabolism section. Overall I believe the book delivers what it promises. Still I wish there was a concise review book with good graphic displays, interesting writing that revealed the beauty and logic of the subject more. I give this book a C to B- overall.

I love this book!!!
This book was my lifeline when I took Biochemistry this past year. Everything is logically organized and the chapters are easy to read and quick to comprehend. The level of detail provided is perfect for an undergraduate level biochemistry course. The diagrams, while simplistic, are easy to understand and remember for use on exams. The only drawback might be a failure to integrate all the different metabolic pathways, but this is a shortcoming found in many textbooks.

Excellent brief presentation of numerous topics in biochem
The book is a very good overview of biochemical processes, covering many significant topics. Detail level is moderate -- not as detailed as an indepth study, which I found a bit disappointing in topics that were of special interest to me, but on the other hand the information is fairly complete for review or introductory purposes. Lots of diagrams supplement the text, and most provide an extra illumination of the topic, which I appreciated. Topics cover: cells and structure, amino acids and proteins, enzymes, antibodies, membranes, DNA and RNA (which could have been left out of this book, since it is covered in much more detail in the Instant Notes in Molecular Biology volume), protein synthesis, recombinant DNA, carbohydrate/lipid/nitrogen metabolism, respiration (Krebs Cycle), and a final chapter that covers muscle contraction, nerve conduction and neurotransmitters -- although the info here is too brief -- and collagen. Viruses are also covered, altho again they are covered in more detail in Instant Notes in Microbiology. I'm using this book along with with Biochemistry by Champe (great illustrations -- more info on the biological processes) to get a basic understanding of biochem. This book could be a great reference for a student/professional review or for a quick look-up of processes or concepts. Brief mention is made, also, of medical conditions resulting from errors, mutations, or deficiencies in the topics covered, but I would like to have seen more of this type of information (e.g., the realistic consequences). Otherwise, very pleased with the book, both information contained in the text and the layout of the diagrams.

Great supplement for instructor or student of biochemistry
As an instructor of introductory biochemistry, I have found this book to be an invaluable supplement when preparing lectures. The general topics found in any 1st year biochemistry text are neatly grouped in 14 broad sections which are again grouped in several concise but informative subsections which deal with very specific topics. Each specific topic is neatly organized and contains the essential information and figures needed to understand that specific material. Although there are no photographs or color diagrams, the line diagrams are very clear and to the point. I encourage both teacher and student (especially students preparing for cumulative exams such as the biochemistry GRE) to check out this title. ... Read more

Book Description

This new edition collects up-to-date information on the purification, activities, antibodies and genes for proteins found in the extracellular matrix, and those known to be involved in cell-cell contact and adhesion. It includes new research on the structure of proteins and their diverse roles in cell communication and metabolite exchange. ... Read more

Reviews (1)

A guidebook
Every major adhesion protein is in there. Not for bedtime reading though, as this book is specifically for those who need this sort of detail for their research. (Although it seems there are more than I would have thought as 5 people rated my initial version of this review) ... Read more

Book Description

THE BIOCHEMISTRY OF HUMAN NUTRITION: A DESK REFERENCE, SECOND EDITION, presents definitions and descriptions of all of the nutrition-related biochemical terms and concepts necessary to understand nutrition science. Each topic is written so that readers can gradually become familiar with or reacquaint themselves with the terminology. ... Read more

Reviews (6)

An interesting book
I teach a course in thermodynamics for college students in biology, as such, I thought the book could be useful, perhaps the new textbook for my course.
Possitive things:
* you will find real thermodynamics, biology and also historical notes in the book.
* there are not too many books that blend biology and thermodynamics in forms acceptable to biologist and physicists, this one does.
* it has an interesting selection of subjects

Problems:
* most of the time it has TOO many words, for those that like concise presentations, it is a problem. There are no evident forms to distinguish essential from accesory
* there is a bias towards bio-chemistry that introduces some additional difficulties for people with other backgrounds

My recommendation to the students
Main text: Kondepudi and Prigogine. Modern Thermodynamics
(extremely clear, concise and with historical notes but little biology)
Second text: Biological Thermodynamics by Haynie

Exciting!
Although Mrs. Faversham is revealed as the murderer in the first third of the book, the joy is in the chase. Dr. Haynie's Inspector Thorndyke is a valuable addition to mystery fiction. Although the subplot about the stuttering pan flute player seemed a little belaboured.

Good Scientific Text
This book is cleverly written. What comes through on every page is Dr. Haynie's breadth of knowledge and enthusiasm for his subject. Dr. Haynie proved that a good scientific text need not be boring. Students who want to learn how thermodynamics relates to everyday life and how their body works will love this book.

This book might become a classic
I'm a Ph.D. student in computational modeling specializing in applications in physics and bioinformatics. My bachelor's degree is in biophysics. I have read numerous biosciences books and texbooks by leading authors. In my opinion this book is one of the best biophysics books I have ever read. I found this book accessible, which is important for students, and yet engaging. The author provides broad coverage of the subject and thoroughly explains basic concepts. For instance, the first law is covered in its own chapter, as is the second law. There are two chapters of Gibbs free energy, with many practical applications, and one on statistical thermodynamics. The chapter on kinetics is an appropriate complement to a book whose main subject is thermodynamics. The final chapter reads like a popular book, introducing students to a number of very interesting and exciting areas for research. This is truly a unique textbook. My guess is that this book might become a classic.

yuk
I thought this book was very confusing and it assumed I knew all about old scientists and so on. The easy bits were labored and the hard bits went too fast. There was a really wierd question about why is it sensible to think stars are gods for instance???!!! ... Read more

Book Description

The text provides an introduction to microarray technology, then moving on to image analysis, data analysis, cluster analysis, and beyond.
With all chapters rewritten, updated, and expanded to include the latest generation of technology and methods, Guide to Analysis of DNA Microarray Data, Second Edition offers practitioners reliable information using concrete examples and a clear, comprehensible style.
This Second Edition features entirely new chapters on:
* Image analysis
* Integrated analysis, and systems biology
* Experiment design
* Interpretation of results
* Automated analysis,
Intended for readers seeking practical applications, this text covers a broad spectrum of proven approaches in this rapidly growing technology.
Additional features include further reading suggestions for each chapter, as well as a thorough review of available analysis software. ... Read more

Book Description

This book provides a systematic introduction to the field of enzyme-catalyzed reactions. The content develops from monosubstrate to bisubstrate to trisubstrate reactions, concluding with nonhyperbolic rate equations and allosteric and cooperative effects. Because it outlines the subject in such a way that it builds from less complicated to more demanding kinetic models, it can be used as a textbook for students of biochemistry and molecular biology. The author stresses the importance of graphical representation of kinetic models by frequent use of such mathematical models in the form of double-reciprocal plots. In addition, special attention is paid to isotope exchange studies, kinetic isotope effects, and the statistical evaluation of initial rate and ligand binding data. ... Read more

Reviews (2)

BACK COVER
As scientific attention turns in the post-genomic era,
once again, to the properties of proteins, and particularly
to their preeminet role as catalysts, Professor
Leskovac's book, Comprehensive Enzyme Kinetics, will
have to be on every shelf. It will, however, rarely
find itself on the shelf, but much more in the hands
of researchers who will daily deploy in the laboratory
its wealth of useful information. Prepared under the
eye of W.W. Cleland, this demiurge of enzyme kinetics,
this magnum opus earns its title "comprehensive".
The systematic organization of the volume, which somehow
manages completeness in just over 400 pages, leads
the reader to a target subject easily. The clarity of
exposition will be as welcome to the experienced
kineticist as it will be to the beginner. This volume
is a singular achievement.
Richard L. Schowen, Professor
University of Kansas

BACK COVER
BACK COVER
"Comprehensive Enzye Kinetics" is an excellent
addition to the enzyme kinetics litarature.
It touches on all of the topics in the various
areas of kinetics that might be of interest to
the enzymologist. It will make a fine classroom
reference text.

Herbert J. Fromm, Distinguished Professor
Iowa State University ... Read more

Book Description

DNA microarray, or DNA chip, technology is a new and powerful means of discovering, characterizing, and analyzing genes and their expression patterns. The potential of this technology is huge and its applications are widespread across the many fields of biological and biomedical research. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. Designed to extend and to complement the information in the best-selling laboratory manual Molecular Cloning, and presented in the same clear, user-friendly format, this book is an essential resource for investigators studying the molecular profiles of gene expression in any experimental system. ... Read more

Reviews (1)

Very useful
This book is very much like its well known predecessor, the currently 3 volume Molecular Cloning Manual with which it shares an editor and a similar title (in fact, it could pass as volume 4).
Overall it gives a good coverage of spotted microarray technology starting from the preparation of probes and slides to sample preparation and hybridization. In addition to expression profiling areas covered include uses of microarrays for analysis of chromatin immunoprecipitation samples, DNA copy number determination, and detection of genetic polymorphisms (oligo arrays). Tissue-arrays and micro-dissection techniques for sample preparation are also described. The bioinformatics section is less extensive than the experimental parts, but the chapters on clustering, self organizing maps and databases serve as good introductions to these areas. I especially liked the image acquisition, normalization and quality control sections.These reviews presented their material in a very clear and sensible way.
Each chapter starts with a short summary of the relevant background. These introductions are very concise, straightforward, jargon-free and up to date in their references. They are written by leading experts of their fields. In addition, there are several "Information Panels" with similar qualities, covering somewhat more general background material.
This is a very nice looking book; it is a pleasure to look at and to hold. I am sure every lab that uses microarrays could benefit from it. ... Read more

Book Description

The second edition of Horizontal Gene Transfer has been organized to provide a concise and up-to-date coverage of the most important discoveries in this fascinating field. Written by the most prominent gene transfer and genome analytical scientists, this book details experimental evidence for the phenomenon of horizontal gene transfer and discusses further evidence provided by the recent completion of genomic sequences from Archea, Bacteria, and Eucarya members. The relevance of horizontal gene transfer to plant and metazoan taxonomy, GM foods, antibiotic resistance, paleontology, and phylogenetic reconstruction is also explored. Horizontal Gene Transfer is essential for microbiologists, geneticists, biochemists, evolutionary biologists, infectious disease specialists, paleontologists, ecologists, and researchers working in plant/animal systematics and agriculture with an interest in gene transfer. This includes scientific researchers from government and industry concerned with the release of genetically modified organisms.

Up-to-the-minute reviews, maps, conclusions, urls to relevant websites and colour figures.
Unique chapters, for example one written by paleontologists presents data for horizontal gene transfer from fingerprints form the fossil record. ... Read more

Reviews (1)

Traditional Darwinists will be astounded by this book.
One of Darwinism's favorite demonstrations of contemporary evolution is the development of resistance to antibiotics by bacteria. In this book we learn that the most frequent mechanism for this development is the uptakeof resistance plasmids, not mutations in genes the bacteria already posess.Even more startling, resistance plasmids often come from dead cells, wherethey can remain viable. This finding strengthens the likelihood that lifefrom space could play a role in evolution.

With dozens of otherwell-documented examples, the book confirms the importance of horizontalgene transfer in evolution. The range and the capability of knownmechanisms are expanding rapidly. If you're interested in whereevolutionary science is headed, check it out! ... Read more

Reviews (1)

a good book in bioconjugate chemistry area
It is hard for a chemistry major student to switch to biochemistry area. When a chem student try to read the big biochemistry textbook, he will be dizzy because of so many reaction equations and biocircles. To his most surprise, those equations are quite different with what he learned in origanic lecture. What shall he begin to go into the new world? Read Bioconjugate Technique --- this book will give Refresh you! ... Read more

Book Description

From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process—clarifying principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzyme kinetics for successful applications of biocatalysis and bioprocess technologies in the food, chiral drug, vitamin, pharmaceutical, and animal feed industries. ... Read more

Book Description

Are soy isoflavones neuroprotective? Just how different is one species of Echinacea from another? Which phytochemicals will be effective as therapeutic agents in vivo? Supported by solid scientific research, Phytochemicals in Nutrition and Health helps provide answers to these and other probing questions concerning the mechanisms of action associated with beneficial phytochemical groups. It examines new areas such as the efficacy and safety of medicinal herbs, the use of biotechnology to manipulate and enhance the phytochemical profiles of various plants, and the pharmacokinetics of phytochemicals in humans.The editors also expand discussion presented in their previous books on phytochemicals. They explore new research on phytochemicals in the Vaccinium family (cranberries, blueberries and bilberries), wine, and oilseeds, and the biological activity of Echinacea in humans. Additional chapters present new information about isothiocyanates, lycopene, carotenoids other than beta-carotene, tocotrienols, and phytoestrogens. Highlighting phytochemicals that have significant potential for promoting health or preventing disease, Phytochemicals in Nutrition and Health expands discussions of appropriate research methodologies and new technologies in this exciting field. ... Read more

Reviews (1)

More than the usual "detox" book.
This is a book written by an Orthomolecular doctor at his best. What you get here is much more than "how toos". Detoxification is about working from the fundamentals of a system and out from there. Dr. Baker, in speaking about this subject, gives a great example of how balance and imbalance, in healing, has always made perfect sense. This is a very enlightening and informative set of ideas that can help open new ways of thinking. Not, "way out - new age" concepts, but common sense connections about how our choices effect us and how we can be empowered to make changes to heal. I recommend this highly and also for anyone that wants to get a very good glimpse at how a good Orthomolecular doctor thinks about things. ... Read more