Book Description

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:

-Proteomics
-Glycoprotein Mapping
-Natural Products Dereplication
-Lead Identification Screening
-Open-Access LC/MS
-In Vitro Drug Screening

Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject. ... Read more

Book Description

Now in its sixth edition, this book is the definitiveintroduction to chemical engineering principles and calculations.A CD-ROM andcomputer disk are included, offering worked out problems for each section of the book,plus POLYMATH, FORTRAN programs, and YAW's data. Coversthe principles and techniques of chemical engineering involving gases, vapors, liquids andsolids; shows how to formulate and solve problems in chemical engineering; anddescribes the proper use of units, physical properties and computers in solving material andenergy balances.For chemical engineers and technicians, andprofessionals in the fields of environmental engineering and petroleum engineering. ... Read more

Reviews (2)

solving simultaneou material and energy balance
When coal is distilled by heating without contact with air, a wide variety of solid, liquid, and gadeous products of commercial importance is produced, as well as some significant air pollutants. The nature and amounts of the products produced depend on the temperature used in the decomposition and the type of coal. At low temperatures(400 to 750 Centigrade)the yield of synthesis gas is small relative to the yield of liquid products,whereas at high temperatures (above 900 Centigrade) the reverse is true.For the typical process flowsheet,shown in Figure P6.23:
(a)How many tons of the various products are being produced?
(b)Make an energy balance around the primary dislillation tower and benzol tower.
(c)How much (in pounds) of 40% NaOH solution is used per day for the purification of phenol?
(d)How much 50% Sulfuric acid is used per day in the pyridine purification?
(e)What weight of Sodium Sulfate is produced per day by the plant?
(f)How many cubic feet of gas per day are produced? What percent of the gas (volume)is needed for the ovens?

A fantastic book
Basic Principles and Calculations in Chemical Engineering is an excellent text book. The First Chapter explains essential definitions and informations that we need before studying Chemical Engineering. This Chapter also explains English unit system. In overall, the book in very useful for teaching Chemical Engineering undergraduate students. It helps the lecturers how to teach and the students how to learn material and energy balance which in essential to know for all chemical engineers. The only problem with this book is the English units which are not currently used very often. If the author could change the English units to SI units, it would be great. ... Read more

Book Description

One of the greatest challenges facing chemists and chemical educators today is conveying the central importance and relevance of chemistry to students and society at large. The new edition of Chemistry Connections highlights the fundamental role of chemical principles in governing our everyday experiences and observations.

Introductory chemistry students and educators as well as laypersons with an inquisitiveness about the world around them will find the book an informative introduction to the context of chemistry in their lives. The book is written in a lively question-and-answer format with presentations in both lay and technical terms.

* Two levels of explanations: general, accessible ones highlight the chemical essence of the phenomenon; and technical ones using chemical principles provide more in-depth interpretation
* Indexing of questions according to key principles or terms enhances instructional use
* Figures and 3-D chemical structures illustrate the chemical concepts presented
* References to related World Wide Web sites for further exploration provide inexpensive and convient access to related information.
* Color plates enhance connections between specific topics ... Read more

Reviews (4)

An absorbing intermediate to advanced level chemical text
Now in an updated second edition, Chemistry Connections: The Chemical Basis Of Everyday Phenomena is an amazing volume with chapters based around answers to questions such as "What causes an egg to crack if it's boiled too rapidly?"; "Why do carbonated drinks go flat as they warm?"; "Why do lightsticks glow?"; "How does a timed-release medicine work?"; and much, much more. The collaborative effort of Kerry K. Karukstis (Professor of Chemistry, Harvey Mudd College) and Gerald R. Van Hecke (Professor of Chemistry, Harvey Mudd College), Chemistry Connections is an absorbing intermediate to advanced level chemical text that makes learning chemistry a lot of fun in some unique but quite effective ways.

there are better alternatives
Overall this book and is fairly successful in its aim of explaining a selection of everyday chemical phenomena in terms accssible to most people. There are a couple of points which really let it down though.
First, the presentation of the material and the diagrams could be greatly improved. For example, there is a "3-D" structure of EDTA given. In fact, it just seems to be a 2-D Chemdraw diagram pasted in to Chem3D! It gives no sense of how the dispostion of the oxygen and nitrogen atoms allow EDTA to surround the metal centre thus making it an effective metal sequestering agent.
Second, certain sections go in to extraordinary detail concerning the physical chemistry of certain phenomena. Rather complicated equations and diagrams are presented which don't aid the reader in really understanding conceptualising the processe which are described.
Third, annoyingly, temperatures are presented only in Fahrenheit. Hello!? Did the authors not consider that they may have readers outside of the US.....
(...)

Great teacher resource
I found Chemistry Connections very interesting and informative. I am a high school science teacher and I already have a strong background in chemistry. The format presents infomation on each question at multiple levels of sophistication, from introductory information accessible without much knowledge of chemistry to in-depth information on specific molecular structures and interactions. This book would be a great resource for chemistry teachers. My only critisism is that the writing style could be a bit more engaging.

Fascinating without forsaking the science
Chemistry Connections is an excellent, well-written book that I found extremely easy and fun to read. It is a fascinating book for both the layperson and the scientist, presenting explanations of everyday phenomena that all of us have wondered about at one time or another. Things like household cleaners, paper money, seashells, shampoo, and chili pepper are explained on a simplified chemical basis, and then on a more detailed scientific basis. Chemical structures and some reactions are presented, as well as very current references and websites on each topic. This has got to be the most entertaining chemistry book I have every read! ... Read more

Book Description

A best-selling mechanistic organic chemistry text in Germany, this text's translation into English fills a long-existing need for a modern, thorough and accessible treatment of reaction mechanisms for students of organic chemistry at the advanced undergraduate and graduate level. Knowledge of reaction mechanisms is essential to all applied areas of organic chemistry; this text fulfills that need by presenting the right material at the right level. ... Read more

Reviews (1)

Ok look at corrosion
This textbook was my senior level undergraduate text on corrosion. I would classify it as average. The writing is somewhat ambiguous in spots. This was reinforced as I read it a second time in preparation for PhD qualifying exams.

Problems with it:
1. Inconsistent notation. Many reaction potentials are subscripted as a anodic, but the Nernst equation immediately following is written for the cathodic form of the rxn.
2. The treatment of the Nernst equation is lacking in detail, particularly in regard to the choice of reference states. The notion of reaction affinity is not mentioned.
3. Mixed potential theory is introduced without a clear description/justification for writing all reactions in their cathodic form. I found this confusing on the first time through.
4. In the section on high temperature oxidation, a standard defect notation, like Kroger-Vink, is not used.
5. I found the descriptions of some of the methods for measuring overpotentials less than clear.

The author is apparently now deceased, so it is doubtful the book will be updated. If you are a teacher looking for a corrosion book, I would suggest looking elsewhere. ... Read more

Book Description

From the reviews of the First Edition: "The book has admirably met its stated goal. The whole gamut of surface and colloid science has been presented in a comprehensive manner without any undue oversimplification. The author should be congratulated for his clarity." -Advanced Materials Now in its second edition, this work remains the single most useful introduction available to the complex area of surface and colloids science. Industry expert Drew Myers walks readers through concepts, theories, and applications-keeping the mathematics to a minimum and presenting real-world case studies to illustrate key technological and biological processes. He substantially reorganizes and updates the material to reflect the current state of knowledge in the field, offering new chapters on absorption and biological systems in addition to the important areas of colloid stability, emulsions and foams, monolayer films, surfactants, and wetting. This revision also boasts an improved index, more than 200 new line drawings, general and specific chapter bibliographies, and end-of-chapter problems. Geared to scientists, technologists, and students dealing with colloidal and surface systems and their numerous industrial applications, the book imparts an understanding of the fundamental aspects of surfaces, interfaces, and colloids, which is essential for effective solutions in diverse areas of chemistry, physics, biology, medicine, engineering, and material sciences. ... Read more

Reviews (1)

Great introductory text
My Ph.D. research involves surface and interface science, so I read a lot of texts in this topic area. This book is one of the best introductory texts I have seen to surface and interface science. It is geared towards the undergraduate student in science and engineering who has little knowledge of quantum, solid state, or thermodynamics. The text flows cleanly with lots of simple pictures and diagrams to illustrate ideas. Important equations are included, but the amount of math is kept to a minimum. All the key ideas in surface science are mentioned, such as adhesion, tribology, wetting, oxidation, catalysis, etc. There is adequate mention of applications, technologies, and how they are related together. The book is organized such that each chapter covers a specific topic, and they can be read independently of each other, making it a great reference. I highly recommend this book to anyone who wants to know more about surface or interface science. ... Read more

Book Description

Despite the extensive literature on safety, few tools have been available to help managers quantitatively assess the level of safety management and the quality of the safety practices in organizations. In his consulting practice, Dr. Jim Stewart, a former executive at DuPont, developed such a method, crafting a safety survey centering on a comprehensive questionnaire for employees at all levels, that reveals the true level of corporate commitment to safety.

Managing for World Class Safety first describes the model of safety management that underpins the questionnaire and then demonstrates how this innovative procedure illuminates critical intangibles like management commitment, the enforcement of rules, worker involvement, and injury investigation.

The central part of this book is the description of research at the University of Toronto that applies the questionnaire in comprehensive research at five of the world’s safest companies and five with very poor safety. The questionnaire polled 700 people in the ten companies, "measuring" the level of more than twenty key elements such as:

• The workers’ perception of the priority given to safety
• The belief that all injuries can be prevented
• The extent to which line management takes responsibility/accountability for safety
• How well safety rules are followed and enforced
• The frequency and quality of safety meetings
• The level of recognition to reinforce safety excellence
• In every element, the contrast between the responses from the very safe companies and those from the companies with poor safety was dramatic, clearly depicting where the former succeed and the latter fail

Book Description

In recent years, there has been an explosion of interest in the science of adhesion. Despite its multidisciplinary and undoubtedly industrial character, the wealth of phenomena to be found in the study of adhesion has drawn researchers from many seemingly disparate scientific disciplines. The intention of these books is to provide an updated view of the state of the art of adhesion science and to fill in the rather large gap in the compilation of knowledge related to adhesion science.

This set of two volumes describes adhesion science from three fundamental perspectives: mechanics, surfaces and chemistry. Volume 1 focuses attention on the contribution of mechanic principles and solutions to understanding the fabrication, design, analysis, and testing of adhesive bonds. It also offers a comprehensive overview of the current understanding of stresses, deformation, and fracture parameters associated with a range of adhesive bonds. Volume 2 dea ... Read more

Book Description

This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Cheminformatics experts from large pharmaceutical companies, as well as from cheminformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process.

With the user rather than the developer of cheminformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using cheminformatics tools -- from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition.

An invaluable resource for drug developers and medicinal chemists in academia and industry. ... Read more

Book Description

Throughout the world, milk and milk products are indispensable components of the food chain. Not only do individual consumers use liquid milk for beverages and cooking, but food manufacturers use vast quantities of milk powder, concentrated milks, butter, and cream as raw materials for further processing. Effective quality assurance in the dairy industry is needed now more than ever. This completely revised and expanded Third Edition of Dairy Microbiology Handbook, comprising both Volume I: Microbiology of Milk and Volume II: Microbiology of Milk Products, updates the discipline’s authoritative text with the latest safety research, guidelines, and information.

Pathogens have become a major issue in dairy manufacturing. Escheria coli is a concern, and milk-borne strains of Mycobacterium avium sub-sp. paratuberculosis have been identified as a possible cause of Crohn’s disease. Even little-known parasites like Cryptosporidium have caused disease outbreaks. Consequently, a hazard analysis of selected control/critical points (HACCP) in any manufacturing process has become essential to prevent the contamination of food. This volume also:

-Discusses new diagnostic techniques that allow a pathogen to be detected in a retail sample in a matter of hours rather than days
-Provides thorough coverage of dairy microbiology principles as well as practical applications
-Includes the latest developments in dairy starter cultures and genetic engineering techniques
-Offers completely updated standards for Good Manufacturing Practice

Quality control and product development managers, microbiologists, dairy scientists, engineers, and graduate students will find the Third Edition of Dairy Microbiology Handbook to be a vital resource. ... Read more

Book Description

Continues the outstanding coverage of information in the field originally brought together by Temple C. Patton. Representing the expertise of international authorities in the pigment industry, it provides ready access to such topics as the physical and chemical meaning of color, the worldwide market for pigments, the properties and physical relationships of diverse pigments, and the major reasons for using certain types of pigments for particular products. In addition to the updated data in this 3 volume set, are new material on novel organic and inorganic pigments that were not even at the research stage when the 1973 version was published. Most chapters include a new and unique section concerning the effect of the pigment under discussion on human health and on the environment. In light of recent legislative standards, these dicussions have special significance. ... Read more

Book Description

Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories. ... Read more

Book Description

Precipitation Hardening (or age-hardening) is an important technique for the metal-using industries. The process is used to enhance the mechanical properties of a wide range of alloys, notably those based on aluminium, but also embracing some nickel and other non-ferrous alloys as well as certain steels. It is important that the mechanisms that produce this improvement in properties are understood so that the desired properties can be optimised. This book provides a thorough treatment and grounding in the subject for the student of materials science and engineering, as well as guidance, for those using the process in industry and in research. A number of excerpts from classic papers are included, which illustrate the development of precipitation hardening from being an art to a science.


Precipitation Hardening (or age-hardening) is an important technique for the metal-using industries. The process is used to enhance the mechanical properties of a wide range of alloys, notably those based on aluminium, but also embracing some nickel and other non-ferrous alloys as well as certain steels. It is important that the mechanisms that produce this improvement in properties are understood so that the desired properties can be optimised. This book provides a thorough treatment and grounding in the subject for the student of materials science and engineering, as well as guidance, for those using the process in industry and in research. A number of excerpts from classic papers are included, which illustrate the development of precipitation hardening from being an art to a science. ... Read more

Book Description

This best-selling standard, now in its fourth, completely revised English edition, is an excellent source of technological and economic information on the most important precursors and intermediates used in the chemical industry. Its translation into eight languages and the five German and four English editions are clear evidence of the popularity of this book.

'... it is where I look first to get a quick overview of the manufacturing process of a product... Weissermel/Arpe has been serving me for years as an indispensable reference work.' (Berichte der Bunsengesellschaft für Physikalische Chemie)
'It would be unkind and misleading to call this book a poor man's Kirk Othmer, but it could almost be described as an encyclopedia... it is easy to read and one has to admire the authors' dedication and endeavor in getting so much into a single volume. They have provided a book that is interesting reading as well as being an excellent reference. It is a highly recommended book, which I hope the authors will find the energy to continue updating on a regular basis.' (Chemistry in Britain)
'...it should be ready to hand to every chemist or process engineer involved directly or indirectly with industrial organic chemistry. It should be in the hand of every higher-graduate student, especially if chemical technology is not part of the study, like in many college universities...' (Tenside-Surfactants-Detergents)
... Read more

Book Description

Charles Hansen began his work with solvents in 1962, and almost immediately began producing new and groundbreaking results. Since then, his Hansen Solubility Parameters have been extensively used and proven valuable to a variety of industries, including coatings, adhesives, plastics, protective clothing, and environmental protection. They allow correlations and systematic comparisons previously not possible, such as polymer solubility, swelling and permeation, surface wetting and dewetting, the solubility of organic salts, and many biological applications. Until now, however, their seemingly universal ability to predict molecular affinities has been generally taken as semiempirical.Moving beyond the Hildebrand and Flory theories, Hansen found that his approach not only quantitatively describes hydrogen bonding and polar bonding in many types of systems, but in fact agrees with and extends the very general Prigogine theory. This explains why the correlations all seem to fit with an apparently "universal" 4: it results from the validity of applying the geometric mean rule to describe dispersion, permanent dipole-permanent dipole, and hydrogen bonding interaction in mixtures of unlike molecules. Hansen Solubility Parameters provides new tables of previously unpublished correlations and parameters. The author illuminates his text with practical examples related to coatings, biological systems, pigments, and fibers, and takes a general approach that makes this reference ideal for predicting compatibility, adsorption on surfaces, orientation toward materials of similar affinities (self-assembly), and other phenomena associated with solubility and affinity. Chemists, chemical engineers, and biochemists will find this book-the collected work and experience of the father of its concept-intriguing for its theory and invaluable for its data. ... Read more

Book Description

For centuries the transformation of grapes into wine has been the focus of much scientific research but it was not until the nineteenth century that the role of yeasts in alcoholic fermentation was discovered. Since this discovery the findings of chemists, biochemists and microbiologists have led to controlled conditions in winemaking, producing more varied and higher quality wines.

Handbook of Enology Volume 1: The Microbiology of Wine and Vinifications uniquely combines scientific knowledge with the description of day-to-day work in the first stages of winemaking, from grape-picking to the end of the fermentation processes. It discusses the scientific basics and technological problems of wine-making and the resulting consequences for the practitioner, providing an authoritative and complete reference manual for both the winemaker and the student. This text will be invaluable to winemakers, students of enology or vinification and chemists interested in winemaking. ... Read more

Reviews (3)

Secrets of French winemakers
It's very difficult to find good English-language descriptions of French winemaking practices, so this book fills a rare and valuable role. Both volumes in this series are excellent complements to the standard winemaking texts, are well-written and comprehensive.

Better than "wine science".
Pretty comprehensive, and more in depth than most others, this is worth investigating if you're into the topic. Easy to read translation helps.

Very Technical But Worth The Effort
I was given this book by a friend of mine studying enology at UC Davis. I work in the vineyard/winery industry (trellising) and needed a basic understanding of vineyard and winemaking operations. While this book is quite technical at times, and it is long, it is a rewarding read and base of information for the layperson or someone employed in a related industry. The tables and appendix of info is substantial, and while I am no chemist (my degree is in history), the writing was clear enough for me to follow along the majority of the time. If your interest in the field is strong and you can keep reminding yourself that this really is a textbook, the end result is a mini degree in Enology! ... Read more

Book Description

Surpassing its bestselling predecessors, this thoroughly updated third edition is designed to be a powerful training tool for entry-level chemistry technicians. Analytical Chemistry for Technicians, Third Edition explains analytical chemistry and instrumental analysis principles and how to apply them in the real world. A unique feature of this edition is that it brings the workplace of the chemical technician into the classroom. With over 50 workplace scene sidebars, it offers stories and photographs of technicians and chemists working with the equipment or performing the techniques discussed in the text. It includes a supplemental CD that enhances training activities. A CD containing a sample LIMS system is also available to professors who adopt this book.The author incorporates knowledge gained from a number of American Chemical Society and PITTCON short courses and from personal visits to several laboratories at major chemical plants, where he determined firsthand what is important in the modern analytical laboratory.The book includes more than sixty experiments specifically relevant to the laboratory technician, along with a Questions and Problems section in each chapter. Analytical Chemistry for Technicians, Third Edition continues to offer the nuts and bolts of analytical chemistry while focusing on the practical aspects of training. ... Read more

Reviews (1)

Teaching Jewel!
This book would make an excellent text for any undergraduate analyticalchemistry course.It represents the real world applications of a varietyof analytical techniques.As a chemist in a pharmaceutical lab and anassociate faculty member, I highly recommend this text/reference. ... Read more

Book Description

Broadly describes the essential topics of the organic chemicals industry
In the past two decades, the organic chemicals industry has undergone unprecedented restructuring, complicated feedstock problems, and massive shifts of capacity to developing countries. In the developed world, specialty chemicals have gained increasing significance. Although the fundamentals of organic chemical and polymer production have remained largely constant, one needs to be aware of the economic, structural, and political changes in the industry in order to understand its current state.
This much-expanded Second Edition of Industrial Organic Chemicals presents the various technologies and processes involved in the organic chemicals industry as an organized body of knowledge. It describes the chemistry of the seven basic building block chemicals and their derivatives, how they are manufactured, their economic importance, uses, and associated environmental issues. Also covered are two topics essential to an understanding of modern industrial chemistry-catalysis and polymer synthesis.
Key additions to this Second Edition include discussion of:
* Sustainability and "green" chemistry
* Dendrimers
* Metallocenes
* Chemicals in biotechnology
* Specialty chemicals for pharmaceuticals, electronics, fire retardation, fuel additives, foods, and other uses
* Economic, political, and social concepts for understanding future directions of the industry
Industrial Organic Chemicals, Second Edition presents the chemistry of both large-scale and specialty products while taking into account important political, environmental, and economic considerations. It provides both a narrative account of the evolution of today's industry from the viewpoint of authors intimately involved with the changes, and an essential reference for chemists, chemical engineers, plastics engineers, petroleum engineers, managers, executives, and policy makers working in and with the organic chemical industry. ... Read more

Book Description

One of the most important objective in this text describes the strategies and approaches for the design of chemical processes. It covers economic (optimization) and environmental issues. The latest design strategies are described, most of which have been improved significantly with the advent of computers, mathematical programming methods, and artificial intelligence. Various methods are utilized to perform the extensive calculations and provide graphical results that are visualized easily, including the usage of computer programs for simulation and design optimization. ... Read more

Reviews (4)

Only good if you want to do simulations
As for using this book for design - I would say that it is marginal at best. If you happen to use Aspen and do everything using a process simulator, this book is pretty good. From and economics/costing standpoint, this book doesn't even come close to Peters & Timmerhaus. Does not have much of a discussion on material selection - a definite drawback. It does include a nice appendix on design heuristics that draws from Walas and other sources.

Fair good
This book is really good for process engineers. I don't know if there is a different edition of the one I have but there's little about CHEMCAD, the book is too focused on other simulation softwares and if you don't have one of those; solving some proposed problems gets really difficult and frustating. Packed with heuriustics on process and equipment design.Excellent choice!

The best book in the market about chemical process synthesis
Covering the main topics in chemical process synthesis an design, this book present a broad view of the state of the art techniques and methods to achieve an optimum design.

With this work, Dr. Seider, et al, have given an invaluable contribution to the teaching of this field, presenting a logical an principle based approach for the "basic plant design", in contrast to the experience based traditional view.

Focusing on the extensive use of commercial process simulators, the book presents an overview of the conceptual basis of process simulation and optimization,but not its mathematical detail, giving the engineer the opportunity to focus on the process instead of focus on the mathematical and computational problem.

The best book in the process design and synthesis field
The ultimate book for process synthesis, that combines the synthesis and design of chemical processes. ... Read more